RNAi – Communicable Diseases Research

Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein

엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제

Article

Published on 2022-12-012022-09-11
Journal: Pharmaceutical Biology
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,

FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling

FACT 소단위 SUPT16H는 BRD4와 연관되어 인터페론 신호 전달 억제에 기여합니다

Article

Published on 2022-08-262022-09-11
Journal: Nucleic Acids Research
[Category] SARS, 유전자 메커니즘,

[키워드] acetylated acetylation Activation Affect association BRD4 cause CBL0137 cells chromatin co-culture complex composed contribute demonstrated Depletion domain enzyme epithelial EZH2 gene transcription Genetic HDAC1 heterodimeric protein histone chaperone IFN IFN signaling IFNs infected cells Infection Influenza inhibit inhibitor interferon interferon signaling interferon-stimulated gene interferon-stimulated genes ISGs killing knockdown lysine mechanism Modification natural killer NK cells pharmacological promote promoter Protein protein stability regulate regulated reported RNAi SARS-CoV-2 shown Signaling SSRP1 subunit suppression SUPT16H Transcription treat viral infections virus-infected cell virus-infected cells viruses Zika
[DOI] 10.1093/nar/gkac645 PMC 바로가기 [Article Type] Article

Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation

바이러스 감염, 세포 사멸 및 염증에서 SARS-CoV-2 뉴클레오캡시드 단백질의 신호 전달 메커니즘

Review

Published on 2022-07-112022-09-11
Journal: International Journal of Biological Sciences
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,

[키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus assembly caused cell cycle cell cycle arrest cell death complex complexes coronavirus COVID-19 Critical Cytokine storms Cytokines ENhance expression facilitate genomic RNA global public health GSDMD IFN-β in viral induce Infection Inflammation inhibit innate immune system life cycle mechanism N protein NF-κB NF-κB signaling NLRP3 NLRP3 inflammasome pathway Proinflammatory cytokine proinflammatory cytokines promote Protein pyroptosis Replication resulting RNA RNAi RNAi pathway SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus Signaling Smad3 stress granule stress granules survival Transcription undergo viral genome viral life cycle viral replication Viral RNA virus worldwide pandemic
[DOI] 10.7150/ijbs.72663 PMC 바로가기 [Article Type] Review

Assessing the developing pharmacotherapeutic landscape in hepatitis B treatment: a spotlight on drugs in phase II clinical trials

Article

Published on 2022-06-012023-06-12
Journal: Expert opinion on emerging drugs
[Category] B형 간염,

[키워드] CpAM Entry inhibitor functional cure HBsAg HBV immunomodulator NAPs Polymerase Inhibitor. RNAi
[DOI] 10.1080/14728214.2022.2074977 PMC 바로가기

Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains

인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계

Article

Published on 2022-06-012022-09-11
Journal: Computational biology and chemistry
[Category] COVID19(2023년), SARS, 치료법, 치료제,

[키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNA. siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization
[DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article

Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells

인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용

Article

Published on 2022-05-062022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 치료법, 치료제,

[키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition. virus VSV-GFP
[DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors

조합 AAV/RNAi 발현 벡터를 사용한 SARS-CoV-2의 생체외 및 생체내 억제

Article

Published on 2022-05-042022-09-11
Journal: Molecular therapy : the journal of the American So
[Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] AAV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adeno-associated virus Antiviral Antiviral agents antiviral RNAi Cell clinically cocktail complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease symptom effective escape mutant escape mutants experiment expression vector flexible Genetic global effort Gut hACE2 in vivo infected cell infected cells intestinal cells intranasal mice mutational escape. N gene N genes organoids pandemic prevented RdRP RNA RNAi SARS virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus suppressed the SARS-CoV-2 therapeutic translation triggers Vaccine vector vectors viral adaptation Viral load viral loads virus wild-type
[DOI] 10.1016/j.ymthe.2022.01.024 PMC 바로가기 [Article Type] Article

RNAi to treat SARS-CoV-2-variant proofing the next generation of therapies

차세대 치료법을 입증하는 SARS-CoV-2 변이체를 치료하는 RNAi

Article

Published on 2022-04-072022-09-11
Journal: EMBO Molecular Medicine
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제,

[키워드] animals Antiviral Antiviral effect approach approved effective Efficacy eliminating market Medicine molnupiravir Older pathology Paxlovid reducing RNA RNAi SARS-CoV-2 siRNAs therapy treat Treatment variant Viral viral replication
[DOI] 10.15252/emmm.202215811 PMC 바로가기 [Article Type] Article

PD-L1 Silencing in Liver Using siRNAs Enhances Efficacy of Therapeutic Vaccination for Chronic Hepatitis B

Article

Published on 2022-03-182023-06-13
Journal: Biomolecules
[Category] B형 간염,

[키워드] checkpoint inhibition HBV Hepatitis immunology PD-L1 RNAi Therapeutic vaccination.
[DOI] 10.3390/biom12030470 PMC 바로가기

Enhanced Antiviral Ability by a Combination of Zidovudine and Short Hairpin RNA Targeting Avian Leukosis Virus

Original Research

Published on 2022-02-162023-08-30
Journal: Frontiers in Microbiology
[Category] E형 간염,

[키워드] avian leukosis virus reverse transcriptase RNAi shRNA zidovudine
[DOI] 10.3389/fmicb.2021.808982 PMC 바로가기 [Article Type] Original Research